This system might be through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the medical reaction to doxycycline must be monitored carefully. Phenytoin, sodium valproate, valproic acid: The effect of barbiturates about the metabolism of phenytoin appears to generally be variable. https://abdulu009kyj3.gigswiki.com/user