Grownup doses of codeine higher than 60 mg are associated with an elevated incidence of adverse reactions and so are not related with better efficacy. The effects of concomitant use or discontinuation of CYP3A4 inducers, CYP3A4 inhibitors, or CYP2D6 inhibitors with codeine are intricate. Below the necessities from the REMS, https://wockusa.com/product/pmg-green/