Gastrointestinal (GI): NSAIDs that block COX-one action have correlations with GI issues as a result of inhibition of the synthesis of gastroprotective agents including PGE2 as well as other prostaglandins. This inhibition causes diminished mucin output by gastric epithelial cells, a lot less bicarbonate secretion, and less epithelial mobile turnover, https://daveyp875vyg3.hyperionwiki.com/user