In the LSD-sure crystal framework, the side chain on the lid residue L209EL2 forms intensive hydrophobic contacts with both equally LSD and surrounding residues in TMs III, IV, and V (Determine 4C). Once the lid moved apart to reveal the binding pocket in simulation, many of these contacts broke. We https://moodjhomedia.com/story2869044/lsd-crystal-for-dummies