Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Contrary to opioids, which bind to µ-opioid receptors during the central nervous program, conolidine modulates alternate molecular targets. A Science Advances research found that conolidine interacts With all the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://paxtonkzjsb.blue-blogs.com/45386076/what-does-alternative-natural-pain-relief-to-replace-traditional-painkillers-mean