Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. As opposed to opioids, which bind to µ-opioid receptors in the central anxious program, conolidine modulates alternate molecular targets. A Science Improvements analyze identified that conolidine interacts Using the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://knoxlwwuu.tinyblogging.com/a-review-of-alternative-natural-pain-relief-to-replace-traditional-painkillers-82372546